Calorie Restriction May Prevent Alzheimer’s Neuropathology

helene · Supporter Joined: 03 Mar 2006 Posts: 366

Around 4.5 million Americans have Alzheimer’s disease (AD). For the time being there are no preventing measures or cure for the disease. Genetic factors play a role in an early-onset AD but not in the most common late-onset-sporadic form of the disease.

A new study gives some evidence that calorie restriction in people who developed AD may stop as well as reverse the symptoms of the disease.
It was found that calorie restriction could trigger activity in the brain that is linked to longevity and prevent AD in that way.

Previous studies have shown the beneficial effects of a low-carbohydrate diet in delaying AD in an experimental mouse models but the new researches give hope that this approach may be beneficial in humans as well. The study done on Squirrel Monkeys showed how a 30% calorie restriction resulted in reduced AD type amyloid neuropathology in the temporal cortex of the brain. The reduced AD type neuropathology led to increased longevity of the protein SIRT1 that is situated in the brain region in charge of functions related to aging related diseases. This study is very important because it explained the relationship between mechanisms associated with the prevention of AD and the effects of calorie restriction on the SIRT1 protein longevity.

Scientists are hoping that this finding will aid in finding a way to prevent and halt the Alzheimer’s disease.

Calorie Restriction May Prevent Alzheimer’s Neuropathology

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