Combining Tramadol (100mg) with Xanax (Generic) - any experiences ?

markmorgan · Newbie Joined: 07 Oct 2007 Posts: 5

Hi - I am a male in my mid 20's
Ive got to taking 2mg of Xanax (generic) a day and 2 x 50 mg of Tramadol about 6 pm every evening. I sleep well (even though I get up a little earlier than usual).
I've also noticed Ive lost a bit of weight - I like to go to the gym but find it difficult to build muscle so ideally don't want to lose too much weight.
Any advice here would be welcome. When I first started the Xanax I had headaches but these seemed to have cleared now. I also drink some grapefruit juice with the Xanax. Do any of you guys think I would have any issues in combining the 2 (they seem to work very well). Is it possible that they are negating the effects of each other. I try not to miss out using the Xanax - but can't say I notice when I do - (its happened twice now).
I've been using both for about a month now.
Also - any tips in not loosing too much muscle (not that I started out with too much would also be really appreciated). My diet is relatively healthy with vitamin supplements (but I do have a sweet tooth)!

thanks
Mark

Guest · Guest

I take both of these medications. Both work well. I take tramadol for back pain and xanax for panic disorder. A word of bigtime caution. Never drink grapefruit juice when you are taking xanax. It is very dangerous. I don't know exactly why, but you prescription bottle should have said something about not drinking grapefruit juice on this medicine. Combining the 2 seem to work fine, although you may feel a bit more tired. Be careful with both of these meds. Both are addicting, especially the Xanax. I have been taking Xanax for six months and it has helped me tremedously, but always have a doctor taper you off this medicine if you need to get off of it. The same goes for the tramadol. It is a non-opiate painkiller that works on your opiate receptors (strange). Not as strong as hydrocodone but works alright. Just be careful with these meds, but I find them very useful, esp. the xanax which is a very good drug for people that have severe anxiety disorder or panic attacks. These meds will not effect your workouts or your muscle gain/loss. That is up to you and just do your routine to keep in shape. Hope this helps

TheGeeze · Posted: 07/19/08 - 22:29 Post subject:

To elaborate and clarify:

It is true that you should not consume grapefruit or grapefruit products with Xanax. Grapefruit’s culprit chemical does not interact directly with your pills. Instead, it binds to an enzyme in your intestinal tract known as CYP3A4, which reduces the absorption of certain medications. When grapefruit juice blocks the enzyme, it’s easier for the medication to pass from your gut to your bloodstream. Blood levels will rise faster and higher than normal, and in some cases the abnormally high levels can be dangerous.

The previous poster was incorrect when he said tramadol is a non-opiate painkiller. Tramadol is a synthetic opiate.

Some controversy exists regarding the dependence liability of tramadol. Tramadol is an opioid with a lower risk of opioid dependence than that of traditional opioids.

Studies into the dependence liability of tramadol show that patients are no more likely to abuse the drug than normal NSAIDs. Despite these claims, it is apparent in community practice that dependence to this agent may occur, but in higher doses and long-term usage. However, this dependence liability is considered relatively low by health authorities. Tramadol is not currently scheduled by the U.S. DEA, unlike other opioid analgesics.

Nevertheless, the prescribing information for Ultram warns that tramadol "may induce psychological and physical dependence of the morphine-type". In addition, there are widespread reports by consumers of extremely difficult withdrawal experiences including acute depression and suicidal urges.

Combining Tramadol (100mg) with Xanax (Generic) - any experiences ?

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