dorsey
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Joined: 12 Jun 2005
Posts: 19
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 Posted: 11/22/06 - 20:23 Post subject: |
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Ok I will try to explain you. Creatinine is a constant constituent of urine. Its amount is sometimes increased in the later stages of nephritis and always in Myasthenia Gravis (OMG). The conception of creatine-creatinine metabolism is that creatinine is formed from creatine during periods of muscular activity. When creatine is transiently free in muscle, then passes by way of the blood, without change, into the urine. Creatine phosphate breaks down in the presence of adenosine ADP to form ATP and it acts as the immediate energy source for the synthesis of ATP for relatively short periods during bursts of contractile activity. The usable life of creatine phosphate is limited, so nce it is used up by muscle action, the muscle must then rely on the adenosine ATP which is synthesized during the chemical activity of the Kreb cycle in glycolysis. And ATP is the essential high-energy package, and it is responsible for delivery of necessary power for the activation of all cells. It is the basic energy unit for life. During muscle relaxation phase, some of the ATP reacts with creatine to form creatine phosphate at the expense of ATP which is reduced to ADP, a low-energy package. This change of reactions continues until such a situation exists when muscle cells can no longer synthesize ATP due to lack of oxygen and essential substrates, so When this happens, a state of muscle rigor mortis exists. Sometimes Myasthenia Gravis patients experience minimal rigor mortis.
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