Hi! Well, you said that paracetamol is considered to be the safest drug in treatment of pain and fever and it's true. But, it can not be used as a sedative since it is not a sedative. It, of course, has some sedative effects but it is not the direct effect of the drug itself. Some doctor thinks that is makes you sleepy, in a similar way as alcohol, due to some toxic reactions inside the body. Your sister has to find the cause and try to solve the problem without any medications. She should talk to his pediatrician as well.
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