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How does a systemic sclerosis happen?

 The time now is 10/11/08 - 15:02
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teodor
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Joined: 26 Jan 2007
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PostPosted: 02/11/08 - 05:16    Post subject: Vote now! Reply with quote
Hello, guys. My friend has been suffering from systemic sclerosis for some period of time. I know something about the disease, but I would like to know how this disease happens. Can anyone help me with this? I would appreciate all your replies. Your help is more than welcomed. Bye, folks!
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domenic
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PostPosted: 02/24/08 - 17:19    Post subject: Vote now! Reply with quote
Hello. Systemic sclerosis is the disease that is related to connective tissue and collagen. Heredity is also important. Some relation to certain HLA antigens is noticed. The important happening is in systemic sclerosis is damage of blood vessels and collagen. As a result, there is an activation of fibroblasts. Skin and joints are mostly affected. There is overproduction of collagen. Digestive system is also commonly affected. I hope this helps. Bye!
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