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Scientists Found Possible Trigger For Alzheimer's Disease

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PostPosted: 12/05/07 - 06:20    Post subject: Scientists Found Possible Trigger For Alzheimer's Disease Vote now! Reply with quote
Researchers found new approach in characterization of neurotoxin structure in Alzheimer’s disease. They believe that Amyloid plaque can be the cause of this neurodegenerative disease. During the research they managed to find transitional step in formation of these amyloid plaque fibrils which are made of small proteins that are toxic to nerve cells and this is the reason why scientist suspect they could be the cause of Alzheimer’s disease.

Researchers found that intermediate form of amyloid is more toxic than final form of the fibrils but the problem is that intermediate form of fibrils is hard for research since it is very unstable. They had to freeze these fibrils in it’s intermediate form and than use scanners and microscopes to study morphology and shape of the fibrils. They concluded that the process of forming layered sheet structure is what seems to be the cause of toxicity and what kills nerve cells.

This finding can be of great importance for pharmaceutical factories since they acknowledged that they have to make drug which will prevent interaction between toxic molecules and nerve cells. This method could also be used for detection of possible triggers in other neurodegenerative diseases.
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