Hi. The cause of urethral pain syndrome is not really known. Some think the cause may be urethral narrowing, others say infectious agents, such as psychology, or neurologic factors, are to blame. My sister was diagnosed with urethral syndrome, turned out she has UTI. The symptoms of UPS are so similar to other urinary problems, and your doctor must first eliminate other diseases. It is very hard to treat illness whose cause is unknown. Antibiotics are usually first in the line of treatment drugs. Some people respond to certain oral pharmaceutical agents.
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