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Jul 27, 2006

Polio (PPS): Symptoms & Treatment

by SirGan

SteadyHealth.com - Health Topics Forum Index -> Articles archive

 Poliomyelitis, often called polio, is a viral paralytic disease. The cause of the disease is one virus called poliovirus which enters the body orally and infects the intestinal wall. Not only that- big problem is that this virus may proceed to the blood stream and into the central nervous system causing muscle weakness and often paralysis. Luckily- eradication efforts led by the World Health Organization have reduced the number of annual diagnosed cases from the hundreds of thousands to around a thousand. There is also one medical entity called PPS or Post-Polio syndrome! Post-Polio Syndrome is a condition that can strike polio survivors anywhere from 10 to 40 years after recovery from an initial attack of polio. Historical fact is that in the US, the last case of "wild" polio (naturally circulating polio that is not caused by the oral polio vaccine) was in 1979 and, except some occasional importations, all cases of paralytic polio since then have been caused by the oral polio vaccine.  

Spreading and paths of infection

Most important thing that there is to know about Polio is that it represents a highly communicable disease which is even categorized as a disease of civilization. It is proven that Polio spreads through human-to-human contact, usually entering the body through the mouth. Most researches have came to the data that in most cases this happen due to fecally contaminated water or food. What is so special about this polio virus? Well, the poliovirus is a small RNA virus that has three different strains and is extremely infectious. How come? Well, the virus invades the nervous system, and the onset of paralysis can occur in a matter of hours. While polio can strike a person at any age, over 50 percent of the cases occur in children between the ages of 3 and 5.

Symptoms of polio infection

The incubation period of polio, from the time of first exposure to first symptoms, ranges from three to thirty five days, thus Polio can spread widely before a polio outbreak is apparent.
After initial infection with poliovirus, virus particles are excreted in the feces for several weeks and are highly transmissible to others in a community.
Every patient must understand that Polio is a viral illness that, in about 95% of cases, actually produces no symptoms at all. The polio virus attacks the nerve cells that control muscle movements. This type of infection is called asymptomatic polio. Symptomatic polio is in all other cases which counts for about the 4% to 8% of all cases. In all forms of polio, the early symptoms of infection are fatigue, fever, vomiting, headache and pain in the neck and extremities.
The illness appears in three forms:
  • A mild form called Abortive polio. Several researches done in the past have came to the data that most people with this form of polio may not even suspect they have it because their condition is limited to mild flu-like symptoms such as mild upper respiratory infection, diarrhea, fever, sore throat, etc…
  • A more serious form associated with aseptic meningitis called Nonparalytic polio. It is found that 1% to 5% of these patients show neurological symptoms such as sensitivity to light and neck stiffness
  • A severe-most serious and debilitating form called Paralytic polio and it occurs in 0.1% to 2% of cases. In paralytic polio, the virus leaves the intestinal tract and enters the bloodstream, attacking the nerves. The virus may affect the nerves that control the muscles in the limbs and the muscles necessary for breathing, causing respiratory difficulty and paralysis of the arms and legs.
Good thing about this disease is that people who have Abortive polio or Nonparalytic polio usually make a full recovery. Problem is that, however, paralytic polio causes muscle paralysis - and can even result in death.

Bulbar polio

The fact is that the virus can affect the motor neurons that control the various muscles of eyeball movements; the trigeminal nerve and facial nerve which innervate cheeks, tears, gums, and muscles of the face; the glossopharyngeal nerve which in part controls swallowing and functions in the throat, tongue movement and taste; the nerve that sends signals to the heart, intestines, and lungs; and the accessory nerve that controls upper neck movement. Therefore, then virus affects any or all of these functions-it is called bulbar polio! It is also very serious form of polio because the mortality rate of bulbar polio ranges from 25 to 75 percent.  

Post-Polio syndrome

Post-Polio Syndrome is one strange syndrome that can strike polio patients anywhere from 10 to 40 years after recovery from an initial attack of polio. PPS is usually a very slow progressing condition characterized by a weakening of the muscles that were previously injured by polio.
Although, there are many theories that tried to explain what's happening in PPS, the fact is that doctors don’t know what causes PPS. Today, there are three theories that try to explain the exact mechanism of this condition:
  1. The first theory is saying that the polio virus reactivates it self again after decades of lying dormant in the patient’s cells. It is still uncertain what activates it.  
  2. The second possibility is the evidence of disbalances in the production of various hormones and neurotransmitters in brain.
  3. The third theory is saying that the nerve cells that were undamaged or partly damaged took over the functions of the dead cells, so-these nerve cells not only had to do their job, but the job of the damaged cells. Over time, these cells become overworked and lead to polio-like symptoms.

Incidence of the condition

Of the 300,000 polio survivors in the US, 1/2 to 1/4 will have symptoms of PPS. If the initial bout with polio was severe, there is a greater chance of developing post polio syndrome.  

Symptoms

Every patient should know that the symptoms of PPS mimic those of the original disease, polio. The symptoms may include:
  • Fatigue
  • Exhaustion
  • Muscle weakness
  • Muscle atrophy (stiffening)
  • Painful joints and muscles
  • Low back pain
  • Sensitivity to cold and heat
  • Sleep disorders
  • Difficult breathing and/or swallowing
  • Muscle twitching
Also, it is proven that patients who had mild symptoms of polio will have mild symptoms of PPS.  

Treatment

Unfortunately - there are currently no effective treatment for the syndrome itself, but, a number of studies have showed that specific exercises can improve muscle strength.
Several studies have showed that intravenous immunoglobin may reduce pain, increase quality of life, and improve strength. Nothing of this is still scientifically proven! Most of the experts from this field are saying that the future of PPS treatment may center on nerve growth factors. It is logical because, since PPS may result from the degeneration of nerve sprouts, growth factors can target these and help to regenerate new ones.

Proven strategies

There are several strategies that are proven to be beneficial to patients:
  • If the person is experiencing increasing muscle weakness, exercise may be needed. Please consult your doctor.
  • Eat a well-balanced diet
  • Be alert to the changes in the body
  • Take note of any new symptoms or any clear or gradual changes
  • Take time to sleep enough
  • Pace yourself
  • Use medical equipment such as canes or crutches or other adaptive medical equipment to ensure that you do not fall
  • Avoid weight gain
  • Minimize alcohol use
  • Take common colds very seriously
  • Get regular checkups with emphasis on the major areas affected by the polio: neuromuscular, circulatory and respiratory, as well as, muscle strength evaluations
  • Discontinue any exercise that causes pain, weakness or muscle fatigue
  • Know your own strengths and limits
  • Get involved or continue with physical therapy

Prevention

Well, now everyone knows that in the United States, it's currently recommended that children have 4 doses of inactivated polio vaccination between the ages of 2 months and 6 years.

This vaccine is developed by Albert Sabin in1964, and since then-it had become the recommended vaccine. The Salk vaccine is based on formalin-inactivated poliovirus. The Sabin vaccine is a live-attenuated vaccine, produced by the passage of the virus through non-human cells. Although it is very effective -the problem with OPV was that, in very rare cases, paralytic polio could develop either in immunized children or in those who came in contact with them. IPV is given by injection. It protects vaccinated persons as well as OPV, but it is not believed to be as effective as OPV in preventing the spread of polio virus among non-vaccinated persons.
What is so special about this vaccine? Well, it is very simple- IPV is a vaccine that stimulates the immune system of the body to fight the virus if it comes in contact with it. Mandatory immunization for polio is recommended at 2 months of age, 4 months of age, 6 to 18 months age, and 4 to 6 years of age.

Polio complications

Every patient should know that polio complications include paralysis, most commonly of the legs. Great danger is that paralysis of the muscles that control breathing and swallowing can be fatal.
In very rare cases, the oral vaccine used to prevent polio can cause polio paralysis in persons who are vaccinated and in people who are close contacts of a vaccinated person. About 8 to 9 cases of paralytic polio caused by the oral vaccine have been reported in the United States yearly. 
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    Article sources
    • www.kidshealth.org
    • www.wikipedia.com
    • www.dhpe.org