2 PAM

From Health Encyclopedia

See

quaternary ammonium compound

Facts (generated by robot; please edit if you find it inaccurate)

• In moderate to severe intoxications, the oxime 2-PAM is given with atropine.
• Intravenous Injection of 2-pyridinivens adoximine methochloride (2-PAM) The drug 2-PAM is given as an antidote for the ingestion of herbicides and pesticides such as parathion.
• The adult dose of 2-PAM is 1 to 2 g IV over 15 to 30 minutes with repeat administration in an hour if muscle fasciculations and weakness are not resolved (6).
• The influence of the organophosphorus poisons on the plasma concentration of 2-PAM is biphasic.
• When 2-PAM is not used soon enough in the course of therapy the organophosphate can destroy the acetylcholinesterase to which it is attached.

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