5,10 methylenetetrahydrofolate

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Broader Terms

folacin

Facts (generated by robot; please edit if you find it inaccurate)

• These results suggest that the concentration of 5,10-methylenetetrahydrofolate is tightly regulated in liver.
• eduThe folate coenzyme 5,10-methylenetetrahydrofolate is an important folate metabolite which cannot be determined directly by HPLC near neutral pH because it dissociates to formaldehyde and tetrahydrofolate.
• Thymidylate synthase (TS) converts dUMP to dTMP by reductive methylation, where 5,10-methylenetetrahydrofolate is the source of both the methylene group and reducing equivalents.
• However, if 5,10-methylenetetrahydrofolate is not reduced to 5-methyltetrahydrofolate, it can either transfer its methylene group to deoxyuridylate to synthesize deoxythymidilate or be oxidized to 5,10-methenyl-tetrahydrofolate, which in turn is converted to 10-formyl-tetrahydrofolate (5).
• 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.
• Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population.
• coli K-12 Enzyme: 5,10-methylenetetrahydrofolate reductase Synonyms: B3941 , MetF Gene: metF Subunit composition of 5,10-methylenetetrahydrofolate reductase = [MetF]4 Molecular Weight of Polypeptide (from nucleotide sequence): 33.
• 68 :5,10-methylenetetrahydrofolate reductaseGo back to enzyme listabbreviated version! For detailed information about 5,10-methylenetetrahydrofolate reductase Reaction = ECTree 1.

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