5 fluorodeoxycytidine

From Health Encyclopedia

Broader Terms

deoxycytidine, halocarbon compound, nucleoside analog

Facts (generated by robot; please edit if you find it inaccurate)

• These data indicate that the complexes contain covalently bound HhaI methylase, poly(FdC-dG), and methyl groups and that 5-fluorodeoxycytidine is a mechanism-based inactivator of the methylase.
• II: If the nucleotide 5-fluorodeoxycytidine is inserted in the methylation sequence (5'-GGFC-3'), the dihydrocytosine beta-elimination is blocked.
• [Hydrolysis of DNA-duplexes, containing 5-fluorodeoxycytidine by restriction endonucleases]Sheflian GIa, Kubareva EA, Gromova ES, Shabarova ZA.
• Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies.
• 21 | 6419-6423 Copyright 1982 by the National Academy of Sciences Metabolism and Mechanism of Action of 5-fluorodeoxycytidine Edward M.
• We have used an oligodeoxynucleotide containing 5-fluorodeoxycytidine as a suicide substrate to capture the enzyme and the dihydrocytosine intermediate.

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