ALD

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adrenoleukodystrophy

Facts (generated by robot; please edit if you find it inaccurate)

  • A mild form of ALD is occasionally seen in women who are carriers of the disorder.
  • BIOCHEMISTRY: X-ALD is a peroxisomal storage disease whereby abnormal function of peroxisomes leads to the accumulation of very long-chain fatty acids (VLCFA) in tissues of the body, especially the brain and the adrenal glands.
  • Contributing Factors: ALD is most common in large active breeds, but small dogs may be affected as well.
  • ALD is particularly well suited for this application since it can allow for deposition on complex non-planar structures at the nanoscale level with controllable thickness.
  • ALD is an X-linked recessive inheritance of a syndrome of Addison disease and cerebral sclerosis.

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