Amyloid protein

From Health Encyclopedia

Contents 1 Used for 2 See for 3 Broader Terms 4 Related Terms 5 Scope Note 6 Facts (generated by robot; please edit if you find it inaccurate)

Used for

amyloid precursor protein, APP (amyloid precursor protein), nexin (protease inhibitor)

See for

nexin

Broader Terms

fibrous protein, glycoprotein

Related Terms

amylin, neuritic plaque, paired helical filament

Scope Note

extracellular glycoprotein that accumulates in certain pathological conditions, e.g., the paired helical filaments of neuritic plaques in Alzheimer's disease and Down's syndrome; use this term for both the precursor and beta form.

Facts (generated by robot; please edit if you find it inaccurate)

• Alzheimer's beta-amyloid protein is covalently modified when dissolved in formic acid.
• The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
• The gene encoded with the template for the beta-amyloid protein is located on chromosome 21 in humans.
• beta-amyloid protein is derived from this larger protein.
• Amyloid protein is removed from the environment due to uptake by microglia.

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