Antigen specificity

From Health Encyclopedia

See

antibody specificity, cell population study, immune response

Facts (generated by robot; please edit if you find it inaccurate)

• Antigen specificity is reduced to a single parameter, and for the time being it is fixed as a frequency of antigen reactive cells (3 per 1000 for B cells and 30 per 1000 for T cells), and the justification for these round figures is given below.
• For these loops, antigen specificity is due primarily to the sidechain conformations, so it is of paramount importance to model these correctly.
• Antigen specificity is the ability of the host cells to recognise an antigen specifically as a unique molecular entity and distinguish it from another with exquisite precision.
• Antigen specificity is demonstrated by the binding of ASHF molecules only to nominal antigen, both during purification and in tests of functional activity.
• There are, of course, no data to indicate that such light chains are pathogenic in man or that any antigen specificity is associated with the elevated levels they report.

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