Antigenic determinant

From Health Encyclopedia

See

antigen, chemical structure, protein structure

Facts (generated by robot; please edit if you find it inaccurate)

• [The terminal monosaccharide of antigenic determinant is involved in the binding of human sperm to specific monoclonal IgA antibody]Chen YL, Ben KL, Cao XM.
• An antigenic determinant is shared by psoriasis-associated p27 antigen and the Fc part of human IgG.
• This antigenic determinant is sensitive to any of six different proteases, is insensitive to periodate oxidation or N-glycanase digestion, and is detectable on a polypeptide synthesized in vitro.
• Every antigenic determinant is extended to N- and C-terminals, only if, accessible amino acid(s) were present after an inaccessible amino acid residue.
• Once the amino acid order of a particular antigenic determinant is known, readily available peptide synthesizers such as those available from Beckman or Applied Biosystems, can be utilized to produce synthetic peptides capable of emulating the binding site of the large ligand.

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