Antipyrine

From Health Encyclopedia

Used for

phenylbutazone, sulfinpyrazone

Broader Terms

analgesic, pyrazole

Facts (generated by robot; please edit if you find it inaccurate)

• Mechanism of Action: Antipyrine is an antiinflammatory/analgesic agent and benzocaine is a local anesthetic.
• Antipyrine is used as an index of hepatic drug metabolism.
• In contrast the role of CYP3A in the metabolism of antipyrine is negligible in case of untreated rats.
• The corresponding pharmacokinetic parameter, CLsys, of antipyrine is as follows.
• (1-3) Antipyrine is a physiologic marker that distributes to a volume as large as total body water in a blood flow-dependent manner and is a surrogate for many lipophilic drugs, including intravenously administered anesthetics.

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