Antiretroviral agent
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- In the setting of absence or altered drug pressure, previously generated resistance mutations remain archived at low levels [16-17], and will re-emerge to confer resistance if the previously used antiretroviral agent is re-introduced [17].
- However, the emergence of resistance to a specific antiretroviral agent is most likely to be the cause of a regimen's failure.
- The fifth consideration is related to concerns about the development of antiretroviral drug resistance if a single antiretroviral agent is used alone to prevent MTCT or if an effective combination of antiretroviral agents is not taken correctly and consistently.
- Right now thats the gold standard for measuring how effective an antiretroviral agent is.
- The selected antiretroviral agent is FDA approved for human use, allows once-a-day dosing, is well tolerated for several years, and is active against most drug resistant HIV-1 strains.
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