Antisense nucleic acid
From Health Encyclopedia
Contents |
[edit]
Used for
[edit]
Broader Terms
[edit]
Narrower Terms
microRNA, small interfering RNA
[edit]
Related Terms
complementary RNA, RNA interference
[edit]
Scope Note
naturally occurring complementary RNA which regulates gene expression by binding to mRNA; or, DNA of genes which code acoantisense RNA; or, synthetic complementary DNA or RNA probes based on antisense sequences.
[edit]
Facts (generated by robot; please edit if you find it inaccurate)
- For example, HAAH antisense nucleic acid is introduced into glioblastoma cells or other tumor cells which overexpress HAAH.
- The activity of an insulin-like growth factor may be modulated, for example, by altering the level of expression of the molecule against which an antisense nucleic acid is designed.
- Antisense nucleic acid is oligonucleotides (usually modified to increase stability) or RNAs.
- Preferably, an antisense nucleic acid is designed so as to be complementary to a region preceding or spanning the initiation codon on the coding strand or in the 3′ untranslated region of an mRNA.
- In a particular embodiment, the antisense nucleic acid is wholly or partially complementary to and can hybridize with a target nucleic acid, wherein the target nucleic acid can hybridize to a nucleic acid having the sequence of the complement of the strand shown in FIG.
Would you like to discuss or post question about Antisense nucleic acid ? Click here !