Antitumor antibody

From Health Encyclopedia

Broader Terms

antibody, neoplasm /cancer immunology

Facts (generated by robot; please edit if you find it inaccurate)

• ], United Kingdom In antibody-directed enzyme prodrug therapy, an enzyme conjugated to an antitumor antibody is given i.
• As illustrated in Figure 1, an antitumor antibody is conjugated to an enzyme not normally present in extracellular fluid or on cell membranes and then these conjugates are localized in the tumor via intravenous infusion.
• The first was that an antitumor antibody is produced after cryosurgery.
• Preferably, the antitumor antibody is directed against a so-called tumor antigen, i.
• This anticipated the much later development of antibody-directed enzyme prodrug therapy (ADEPT) in which an enzyme conjugated to an antitumor antibody is used to convert an administered low-toxicity prodrug to a highly cyto- toxic compound (39).

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