Apoptosis
From Health Encyclopedia
Contents |
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Used for
anoikis, clonal deletion, programmed cell death
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See for
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Broader Terms
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Related Terms
Bax gene /protein, BCL2 gene /protein, immune tolerance /unresponsiveness, survivin
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Scope Note
active process of selective destruction of differentiated cells in multicellular organisms; important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function, hormone-induced atrophy, etc.; apoptosis is a specific mechanism involving self- fragmentation of chromatin.
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Facts (generated by robot; please edit if you find it inaccurate)
- Today, however, apoptosis is implicated in biological processes ranging from embryogenesis to ageing, from normal tissue homoeostasis to many human diseases, and it has become one of the hottest fields of biomedical research.
- TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
- Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases.
- Mounting evidence indicates that the acquired ability to resist apoptosis is a hallmark of most, and perhaps all types of cancer.
- Apoptosis is a process by which cells in a multicellular organism commit suicide.
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