BPDE
From Health Encyclopedia
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Facts (generated by robot; please edit if you find it inaccurate)
- Intriguingly, the (+) BPDE is tumorigenic in rodents, while the (-) BPDE is not.
- BPDE-induced HPRT Mutation BPDE is a carcinogenic in vivo metabolite of benzo[a]pyrene, one of the most well-known combustion products in vehicle exhausts, cigarette smoke, and ambient air.
- It is well established that BPDE is a potent mutagenic and/or carcinogenic agent and should be handled with care.
- Thus, BPDE is a potent inducer of gene mutation in this system.
- However, the molecular basis for high catalytic activity of mGSTA1-1 toward (+)-anti-BPDE is not clear.
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