BRL49653

From Health Encyclopedia

Use

rosiglitazone

Facts (generated by robot; please edit if you find it inaccurate)

• Thus, the combination of dexamethasone and BRL49653 is able to rescue the ability of the antisense-expressing clone GP2-4-2 to differentiate.
• BRL49653 is a more potent activator of hPPAR than troglitazone, whereas SB209501, a structurally related compound, does not stimulate receptor activity.
• As expected, protection of PPAR[gamma] by BRL49653 is still observed (Fig.
• We show here that coexpression of ALBP or ACBP exerts a negative effect on ligand-dependent PPAR transactivation, when tetradecylthioacetic (TTA) is used as ligand but not when the thiazolidinedione BRL49653 is used as ligand.
• In separate experiments we have shown that transactivation by 1 M BRL49653 is completely abolished by the addition of 10 M GW9662 (data not shown).

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