B cell receptor
From Health Encyclopedia
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Broader Terms
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Related Terms
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Scope Note
membrane bound version of the specific antibody immunoglobulins produced by B lymphocytes; when BCR is occupied by antigen and the B cell is stimulated with interleukin 2, the B cell becomes activated to produce antibodies.
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Facts (generated by robot; please edit if you find it inaccurate)
- Clustering of the B cell receptor is not required for the apoptotic response.
- The B-cell receptor is displayed on the surface of the B cell, where it comes into contact with antigens—proteins, carbohydrate molecules, and other pieces of a foreign bacterium, virus, or other pathogen.
- The terminal portion of the Fc region of the B-cell receptor is the part that becomes anchored to the cytoplasmic membrane of B-lymphocyte (see Fig.
- These each have a single immunoreceptor tyrosine-based activation motif (ITAM), shown as a yellow segment, in their cytosolic tails that enables them to signal when the B-cell receptor is ligated with antigen.
- Once a Pre-B-cell receptor is formed, it will send two important signals(this is an important checkpoint): 1) One signal stops rearrangement of the other allele of the HC gene, which ensures, drum roll please.
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