Bicuculline

Broader Terms

The basal ganglia, the deep prepyriform cortex, and seizure spread: bicuculline is anticonvulsant in the rat striatum.
Regulation of 35S-TBPS binding by bicuculline is region specific in rat brain.
The action of bicuculline is primarily on the ionotropic GABAA receptor, which is a ligand-gated ion channel concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target neuron.
Bicuculline is known to block the action of gamma-aminobutyric acid, which is thought to be the primary inhibitory neurotransmitter in the visual cortex.
Hydrastine and bicuculline are shown to be qualitatively and quantitatively similar, with the exception that bicuculline is approximately 100 times as powerful a convulsant as hydrastine.

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