Bone metabolism

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Contents

Broader Terms

metabolism

Narrower Terms

physiologic bone resorption

Related Terms

calcium metabolism, osteopontin, substantia spongiosa

Scope Note

sum of chemical changes that occur within the bones consisting of anabolism (biosynthesis) and catabolism; the buildup and breakdown of molecules for utilization by the bones.

Facts (generated by robot; please edit if you find it inaccurate)

  • Although the importance of selenium for bone metabolism is unknown, some clinical conditions such as Kashin-Beck osteoarthropathy have been associated with selenium deficiency.
  • In the mild type, bone metabolism is closest to that of persons with normal renal function.
  • This, however, requires a greater understanding of the mechanisms through which bone metabolism is affected by microgravity.
  • Most importantly, distorted bone metabolism is reversible when the initial trigger, primarily TNF, is neutralized – suggesting that TNF blockade might not only block bone resorption but also pave the path for effective repair of skeletal damage.
  • Another way to address the question of drug effects on bone metabolism is by analyzing fracture data.

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