Cell mediated cytotoxicity

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Contents

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Used for

ADCC (antibody dependent cell mediated cytotoxicity), antibody dependent cell mediated cytotoxicity

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See for

ADCC

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Broader Terms

immunity

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Related Terms

killer cell

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Scope Note

phenomenon of antibody mediated target cell destruction by nonsensitized effector cells; effector cell is a killer cell possessing Fc receptors; it may be a lymphocyte lacking conventional B or T cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell.

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Facts (generated by robot; please edit if you find it inaccurate)

  • Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
  • Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia.
  • Antibody-dependent cell-mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC.
  • Cell-mediated cytotoxicity is a major part of the way the body protects itself from immune attack and is fundamental in maintaining homeostasis of the immune system.
  • NK cell-mediated cytotoxicity is activated by glycoproteins on the cell surface (activating receptors) and inhibited by MHC-1 with self-peptide bound.
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