Contact hypersensitivity

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contact dermatitis

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• However, the role of IgE the onset of this contact hypersensitivity is still obscure.
• The mechanism of hapten-induced contact hypersensitivity is not yet fully understood.
• Three examples of Type IV reaction : Contact Hypersensitivity is characterized by a reaction at the site of contact with the allergen (cf.
• Because allergic contact hypersensitivity is an immunological phenomenon and because many of the activities of the immune system are governed by the MHC, experiments were next conducted to investigate whether the MHC could exert genetic control over development of DMBA contact hypersensitivity.
• The role of Langerhans cells as the key immunocytes in the afferent sensitizing phase of contact hypersensitivity is well established, but its role in the efferent pathway is less well defined.

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