Corrinoid
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Facts (generated by robot; please edit if you find it inaccurate)
- The corrinoid is 5-methoxybenzimidazolylcobamide, with an OH- group probably present as the upper axial ligand.
- When the corrinoid-R-protein complex gets to the small intestine, the corrinoid is liberated from the R-protein by enzymes made by the pancreas.
- The corrinoid is maintained in the base-off state with a formal equilibrium reduction potential (E'o) at pH 7.
- The corrinoid is involved in this reaction presumably as a redox-active prosthetic group, as deduced from the finding that it has to be reduced to cob(I)alamin prior to the nucleophilic attack on the carbon of PCE (13, 25).
- A likely mechanism is that the 29-kDa corrinoid is methylated by MMA and the methyl group is then transferred by the "A" isozyme of MT2 to CoM.
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