Cytokine
From Health Encyclopedia
Contents |
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Used for
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See for
interleukin (unspecified), leukocyte mediator
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Broader Terms
cell communication molecule, immunological substance
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Narrower Terms
chemokine, hepatocyte growth factor, interferon, interleukin 1, interleukin 10, interleukin 11, interleukin 12, interleukin 13, interleukin 18, interleukin 6, interleukin 7, interleukin 8, interleukin 9, leukemia inhibitory factor, lymphokine, monokine, stem cell factor
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Related Terms
biological response modifier, immunologic substance development /preparation, scavenger receptor
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Scope Note
soluble factors elaborated by cells of the immune system that act on other cells to regulate their function.
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Facts (generated by robot; please edit if you find it inaccurate)
- Captured cytokine is detected using a biotinylated detection antibody and streptavidin-phycoerythrin (S-PE).
- A second antibody (biotinylated) reactive with a distinct epitope of the target cytokine is employed to detect the captured cytokine.
- An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease.
- This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6.
- With the addition of polyclonal antibody (which binds to the antigen-specific polyclonal antibody) conjugated to alkaline phosphatase, and followed by the addition of the color reagent solution, which contains substrat for alkaline phosphatase enzyme reaction, the amount of cytokine is detected.
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