DNA damage

From Health Encyclopedia

Contents 1 Used for 2 Broader Terms 3 Narrower Terms 4 Related Terms 5 Scope Note 6 Facts (generated by robot; please edit if you find it inaccurate)

Used for

clastogenesis, DNA strand break, genotoxicity

Broader Terms

gene mutation

Narrower Terms

pyrimidine dimer

Related Terms

adduct, drug adverse effect, radiation genetics

Scope Note

drug or radiation effects on DNA that interfere with normal function, including conformational distortions and covalent gene mutations.

Facts (generated by robot; please edit if you find it inaccurate)

• Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.
• Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.
• 10, 958-963, February 2004 2004 American Association for Cancer Research Molecular Oncology, Markers, Clinical Correlates Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status Zsofia Kote-Jarai1, Richard D.
• PLoS Biol 2(5): e144 With billions of cells in the adult human body, all replicating and dividing in an environment laden with toxins, radiation, and free radicals, a certain amount of DNA damage is guaranteed to occur.
• Breast Cancer Elev ffb ated DNA damage is significantly associated with breast cancer risk September 16th, 2003 Elevated DNA damage is significantly associated with breast cancer risk.

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