Deferoxamine

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Contents

Used for

desferrioxamine, feroxamine

Broader Terms

chelating agent, hydroxamate

Related Terms

chelation therapy

Scope Note

natural product isolated from Streptomyces pilosus; it forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

Facts (generated by robot; please edit if you find it inaccurate)

  • The combination of iron and deferoxamine is then removed from the body by the kidneys.
  • Theoretically, 100 parts by weight of deferoxamine is capable of binding approximately 8.
  • Deferoxamine is poorly absorbed if taken orally.
  • Deferoxamine is most commonly administered as a slow subcutaneous infusion but continuous intravenous infusion may be required for treating life threatening cardiac complications due to iron overload.
  • To date, only deferoxamine is globally available for the first-line treatment of transfusional iron overload.

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