Diaziquone

From Health Encyclopedia

See

antineoplastic, aziridine, quinone

Facts (generated by robot; please edit if you find it inaccurate)

• Diaziquone is an aziridinylbenzoquinone with properties suggestive of an alkylating agent.
• The enzymatically generated free radical of the antitumor agent diaziquone is analyzed with the help of two analogs where either the aziridine rings (RQ14) or the carboethoxyamino groups (RQ2) were substituted by chlorine atoms.
• Myeloablation with diaziquone: in vitro assessment BH Kushner, S Siena and H Castro-Malaspina The promising antineoplastic agent diaziquone is associated with prolonged aplasia and rare instances of bone marrow necrosis, but only mild extramedullary toxicity.
• Diaziquone is one of a family of aziridinylquinones with anti-neoplastic activity (Figure 1), that have, in addition to redox properties, alkylating activity that is enhanced by a two electron reduction (7).
• Diaziquone is effective in hematologic tumors.

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