Dicumarol

From Health Encyclopedia

Use

alpha benzopyrone

Facts (generated by robot; please edit if you find it inaccurate)

• Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.
• Dicumarol is routinely added to the 3-[4,4-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay to study the role of NAD(P)H:quinone oxido-reductase in drug activation and detoxification.
• Dicumarol is able to impede this cycle.
• Dicumarol is similar to Vitamin K and interferes with the chemical's ability to activate prothrombin.
• Dicumarol is derived from oxidation of coumarin (the plant product responsible for the sweet smell of Melilotus) by the action of fungi in the mouldy hay.

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