Eicosanoid metabolism
From Health Encyclopedia
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Used for
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Broader Terms
fatty acid metabolism, hormone metabolism
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Facts (generated by robot; please edit if you find it inaccurate)
- Whether lower 20:4 levels in n-3 fed animals could rate-limit eicosanoid metabolism is unknown, but epidermal capacity to metabolise arachidonic acid in these animals was found to be closely related to n-6 FA intake.
- Previous studies have shown that LPS induction of eicosanoid metabolism is transcription dependent and that prostaglandin (PG) H synthase is the committed step in the conversion of arachidonic acid (AA) to thromboxane (Tx) B2.
- This alteration in eicosanoid metabolism is observed within 1h, where endothelial cells began to produce large amounts of the prostacyclin metabolite 6-keto-PGF1, but very little of PGE2 and TXA2.
- The function and regulation of eicosanoid metabolism is extremely complex and controversial, but it is known that they function as short-term locally acting hormones.
- Eicosanoid metabolism is further affected by a number of dietary factors.
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