Estrogen receptor

From Health Encyclopedia

Broader Terms

steroid hormone receptor

Facts (generated by robot; please edit if you find it inaccurate)

• The estrogen receptor is a protein with several functional parts: a DNA-binding domain, two activation domains, and an estrogen-binding domain.
• Functional activity of ectopically expressed estrogen receptor is not sufficient for estrogen-mediated cyclin D1 expression.
• The beta form of the estrogen receptor is predominantly expressed in the papillary cystic neoplasm of the pancreas.
• Estrogen receptor is a protein normally found in various reproduction-related tissues such as the breast and uterus.
• Several investigators have demonstrated that fluorescein labeled E2-BSA (E2-BSA-FITC) binds to the cell membrane, suggesting that a form of the estrogen receptor is present within the cell membrane and capable of binding to extracellular E2.

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