F Ara A

From Health Encyclopedia

See

fludarabine

Facts (generated by robot; please edit if you find it inaccurate)

• 19 L/kg, indicating that 2-F-ara-A is distributed and bound to the tissues of the body.
• Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) inhibited DNA polymerase alpha and ribonucleotide reductase.
• These results suggest that inhibition of UV-induced DNA repair by F-ara-A is critical for cytotoxicity and that induction of apoptosis may be conducted by a p53-mediated signaling mechanism to the Fas death pathway.
• F-ara-A is excreted primarily in the urine.
• Although F-ara-A is not a good substrate for this enzyme, the high specific activity of this protein results in efficient phosphorylation of F-ara-A in certain tissues.

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