Familial periodic paralysis
From Health Encyclopedia
Contents |
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Used for
normokalemic periodic paralysis, periodic hypokalemic paralysis
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Broader Terms
inborn metal metabolism disorder, peripheral nervous system disorder
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Related Terms
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Scope Note
heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia; these conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle; frequently associated with fluctuations in serum potassium levels; periodic paralysis may also occur as a non-familial process secondary to thyrotoxicosis and other conditions.
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Facts (generated by robot; please edit if you find it inaccurate)
- Familial periodic paralysis is inherited but may occur without a known family history.
- Privacy Statement 26c9 Diseases Conditions Lab Tests Nutrition Surgeries/Procedures Symptoms Special Topics familial periodic paralysis Definition Familial periodic paralysis is a condition that causes occasional bouts of muscle weakness.
- Familial periodic paralysis is autosomal dominant with a prevalence of 1:100,000.
- Primary or familial periodic paralysis is a group of disorders due to single gene mutation resulting in abnormalities of calcium, sodium, potassium, and chloride channels on muscle cell membrane.
- The onset of paralytic attacks in familial periodic paralysis is often during adolescence, but in most published reports, TPP were found to be between the ages of 20 and 40 years.
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