Folate antagonist

Used for

piritrexim, tetrahydrofolate antagonist

Broader Terms

antimetabolite, vitamin antagonist

Narrower Terms

aminopterin, methotrexate

Facts (generated by robot; please edit if you find it inaccurate)

• 5 wk) (print) ? Fri Nov 23 2001 at 17:39:18 A folate antagonist is any of a group of chemicals which block the formation of nucleotides that require the presence of folate (folic acid).
• Preferably, the folate antagonist is methotrexate.
• Therefore, after high-dose MTX treatment, the cytotoxic effect of the folate antagonist is compensated for by rescue with Leucovorin in low doses only in the normal cell system.
• Explain what a folate antagonist is and how it works, and give examples of such drugs.
• 1992 Oxford University Press research-article Toxicity of the Anticancer Folate Antagonist Trimetrexate in Rats1 MICHAEL J.
• com - explain folate antagonist folate antagonist -- A substance that blocks the activity of folic acid.
• PDF Toxicity of the Anticancer Folate Antagonist Trimetrexate in Rats GRAZIANO et al.
• Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations.