Gene mutation

Used for

mutation

Broader Terms

genetics, molecular genetics

Narrower Terms

chromosome aberration, DNA damage, frameshift mutation, gene deletion mutation, gene duplication, loss of heterozygosity, mutant, point mutation, suppressor mutation

Related Terms

genetic manipulation, mutagen, protooncogene, single strand conformation polymorphism

Scope Note

any detectable and heritable change in the genetic material that causes a change in the genotype and which is transmitted to daughter cells and to succeeding generations.

Facts (generated by robot; please edit if you find it inaccurate)

• Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.
• The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease.
• A single gene mutation is not sufficient for CF, but other CF gene mutations exist.
• When a cancer susceptibility gene mutation is inherited in an autosomal dominant manner, it means that the mutation can be inherited from the mother, or the father, who themselves may or may not have ever had any type of cancer.
• A person who has only one recessive gene mutation is said to be a "carrier" for the trait or disease, but he/she does not have any health problems from carrying this one mutation.