Gene rearrangement
From Health Encyclopedia
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Used for
DNA rearrangement, immunoglobulin class switching, immunoglobulin genetic recombination mechanism, site specific DNA recombination (naturally occurring)
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Broader Terms
genetic recombination, immunogenetics, molecular genetics
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Facts (generated by robot; please edit if you find it inaccurate)
- The bcl-2/JH gene rearrangement is undetectable in Hodgkin's lymphomas: results from the German Hodgkin trial.
- Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu.
- This primer set is expected to generate a 90-160 base pair fragment if a clonal Ig gene rearrangement is present.
- :Extensive gene rearrangement is reported in the mitochondrial genomes of lungless salamanders (Plethodontidae).
- Understanding the regulation of gene rearrangement is important because its products (Ig and TCR molecules) control the development and function of B and T cells and because errors in the process can result in leukemia, lymphoma, or immunodeficiency disease.
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