Genetic effector

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transcription factor

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• In turn, the fact that different anticancer agents share genetic effector cascades renders the genetically encoded programs of apoptosis and senescence highly susceptible to inactivating mutations as a potential cause of chemoresistance.
• Page 18 -globin chromosomal control region The locus control region (LCR) was postulated as a long range genetic effector.
• "If it's included in the model, it must be close to a > genetic effector of the trait".
• On the basis of these observations, we used mice transgenic for hepatitis B virus to determine if HMGB-1 plays a role in the intrahepatic recruitment and patho- genetic effector functions of hepatitis B virusspecific cytotoxic T lymphocytes and other inflammatory cells.
• Patho- genetic effector function of CD4-positive T helper 1 cells in hepa- titis B virus transgenic mice.

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