Genetic silencer
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- A genetic silencer of Na+ channels is hence desirable because complete pharmacologic blockade with TTX is well understood and, in many neuronal types, may be maintained chronically without cell death or upregulation of TTX-resistant channels.
- asp?a=252 Genetic silencer (Access Excellence) Describes a genetic defect that appears to underlie the most common cause of deafness.
- At HMRE there is an association between the components of a genetic silencer and a replication origin (reviewed in 2 ).
- A genetic silencer of Na channels is hence desirable because complete pharmacologic blockade with TTX is well understood and, in many neuronal types, may be main- tained chronically without cell death or upregulation of TTX- resistant channels.
- However, the distinctively benign behavior of types A and AB strongly suggests some additional genetic silencer(s); these could explain the imperfect correlation between genotype and phenotype in Table 3.
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