High endothelial venule

From Health Encyclopedia

See for

HEV

Broader Terms

capillary, lymph node

Facts (generated by robot; please edit if you find it inaccurate)

• xVolume 87 Issue 4 Differential regulation of tissue-specific lymph node high endothelial venule cell adhesion molecules by tumour necrosis factor and transforming growth factor-β1 Y.
• Culture characterization of differentiated high endothelial venule cells from human tonsils.
• It is a ligand for the lymphocyte mucosal homing receptor a4b7, and can also be decorated on high endothelial venules by L-selectin-binding carbohydrate determinants.
• In order for them to work efficiently they have to (cont'd, left column) Click on image above to see TEM Click HERE to see High Endothelial Venule cross section - Homing -go to where "professional" antigen presenting cells, dendritic cells, present antigens to the traveling cells.
• von Andrian Blood-borne lymphocyte trafficking to pe- ripheral lymph nodes (PLNs) depends on the successful initiation of rolling interac- tions mediated by L-selectin binding to sialomucin ligands in high endothelial venules (HEVs).

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