Hydroxycholesterol
From Health Encyclopedia
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Broader Terms
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Facts (generated by robot; please edit if you find it inaccurate)
- 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1).
- 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).
- se 24S-hydroxycholesterol is a side-chain oxidised oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation.
- At least half of the 24S-hydroxycholesterol is excreted in bile in sulfated and/or glucuronidated form or as a corresponding conjugate of 24,27-dihydroxycholesterol (6) (Figure 2).
- In Hep G2 cells 7 alpha-hydroxylation of 26-hydroxycholesterol is not well expressed.
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