Immune receptor

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immunologic receptor

Facts (generated by robot; please edit if you find it inaccurate)

• The CC49-zeta chimeric immune receptor is comprised of the intracellular signaling domains of the TCR CD3zeta protein fused to the single chain scFv of the humanized CC49 antibody, which binds the pan-adenocarcinoma tumor antigen TAG-72.
• Even though each immune receptor is non-specific to its target, the result of all the receptor reactions together will be unique, and thus specific to that antigen.
• The CC49-[zeta] chimeric immune receptor is comprised of the intracellular signaling domains of the TCR CD3[zeta] protein fused to the single chain scFv of the humanized CC49 antibody, which binds the pan-adenocarcinoma tumor antigen TAG-72.
• Expression of this innate immune receptor is therefore not restricted to hematopoietic cells of the myeloid lineage, but is also expressed on subsets of cells of lymphoid origin.
• The mouse model showed that a specific immune receptor is activated early in the pregnancy that results in the pregnancy loss.

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