Intracellular parasitism
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- Successful intracellular parasitism is dependent on the pathogen-driven control of the biogenesis and maturation of the vacuole, allowing the establishment of a replication permissive niche.
- A key to t 31e he adaptation of Hpt as a mediator of Listeria intracellular parasitism is its PrfA dependency.
- One important aspect of understanding the molecular basis of intracellular parasitism is the development of molecular genetic techniques to complement cellular and biochemical studies.
- The extensive metabolic capacity of C burnetii suggests that its obligate intracellular parasitism is a highly evolved state rather than a degenerate condition.
- It appears that the basis of the obligate intracellular parasitism is due to a lack of ATP-generating ability and the need to obtain ATP from the host cell.
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