LDLR

From Health Encyclopedia

See

low density lipoprotein receptor

Facts (generated by robot; please edit if you find it inaccurate)

• Human LDLR is a chain of 839 amino acids organized into several modular domains.
• The LDLR is regulated by cholesterol levels, such that cells incubated in a cholesterol-free media upregulate LDLR expression the addition of LDL or cholesterol whichcan lead to a decrease in receptor expression.
• The hypothesis that a pH-induced intra-molecular interaction within the LDLR is responsible for ligand displacement is under investigation.
• The importance of the LDLr is evident in individuals with familial hypercholesterolemia (FH), a condition that results from an inherited defect in the LDLr.
• LDLr is also overexpressed in many forms of human cancer.

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