L 694,458
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- Similar to L-680,833 and L-683,845, L-694,458 is highly selective for the human enzyme, being much less active against elastase and elastase-like enzymes from other species, including rhesus monkey.
- Disposition of L-694,458 in rats and rhesus monkeys.
- Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching.
- Disposition of L-694,458 in Rats and Rhesus Monkeys Styliani H.
- Hartner, Randolph Greasham and Michel Chartrain, (1997): Process development for the production of the (S)-acid precursor of a novel elastase inhibitor (L-694,458) through the lipase-catalyzed kinetic resolution of a beta-lactam benzyl ester.
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