L iduronidase

From Health Encyclopedia

Use

O glycosidase

Facts (generated by robot; please edit if you find it inaccurate)

• A model of the catalytic requirements of alpha-L-iduronidase is proposed.
• alpha-L-Iduronidase is a lysosomal enzyme, the deficiency of which causes mucopolysaccharidosis I (MPS I); a canine MPS I colony has been bred to test therapeutic intervention.
• Thanks and have a prayerful day!--L-iduronidase is an enzyme that catalyses the hydrolysis ofglycosides of the sugar L-iduronic acid.
• Alpha-L-iduronidase is just an enzyme, and enzymes typically do not garner much attention from managed care medical and pharmacy directors.
• -L-iduronidase is synthesised in the endoplasmic reticulum (ER) as a 653-amino-acid polypeptide (following signal peptide cleavage) and is glycosylated with six N-linked oligosaccharides to produce a 74-kDa precursor molecule (Figure 1).

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