L selectin
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Facts (generated by robot; please edit if you find it inaccurate)
- The CRD in L-selectin is followed by a domain with primary sequence similarity to the EGF precursor.
- L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice.
- L-selectin is constitutively expressed on the surface of most leucocytes and is important for tethering and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs (e.
- Our past studies have demonstrated that L-selectin is required for leukocyte migration into sites of chronic inflammation (1), is expressed on subsets of memory lymphocytes (2), and is required for the generation of rapid humoral immune responses to antigenic challenge (3).
- L-selectin is also known as LECAM-1, LAM-1, Mel-14 antigen, gp90 mel, and Leu8/TQ-1 antigen.
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